Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration

Shana Elbaum-Garfinkle, Clifford P. Brangwynne

Research output: Contribution to journalShort surveypeer-review

24 Scopus citations

Abstract

Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.

Original languageEnglish (US)
Pages (from-to)531-532
Number of pages2
JournalDevelopmental cell
Volume35
Issue number5
DOIs
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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