Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration

Shana Elbaum-Garfinkle, Clifford Paul Brangwynne

Research output: Contribution to journalShort survey

19 Scopus citations

Abstract

Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.

Original languageEnglish (US)
Pages (from-to)531-532
Number of pages2
JournalDevelopmental cell
Volume35
Issue number5
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Developmental Biology

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