Abstract
Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.
Original language | English (US) |
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Pages (from-to) | 531-532 |
Number of pages | 2 |
Journal | Developmental cell |
Volume | 35 |
Issue number | 5 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Biochemistry, Genetics and Molecular Biology
- Molecular Biology
- Cell Biology
- Developmental Biology