Liquid demixing in elastic networks: Cavitation, permeation, or size selection?

Pierre Ronceray, Sheng Mao, Andrej Košmrlj, Mikko P. Haataja

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In cells, phase-separated liquid condensates interact mechanically with surrounding elastic networks such as chromatin and cytoskeleton. By considering the trade-offs between elastic, wetting, and interfacial energies, we theoretically show that three droplet phases can be thermodynamically stable: macroscopic droplets that either cavitate or permeate the network, and mesh-size-limited microdroplets. We show that network strain stiffening further enhances this latter size-limitation effect. Our theory predicts the possibility of yet-unobserved droplet phases in the cytoplasm and nucleoplasm.

Original languageEnglish (US)
Article number67001
JournalEPL
Volume137
Issue number6
DOIs
StatePublished - Mar 2022

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'Liquid demixing in elastic networks: Cavitation, permeation, or size selection?'. Together they form a unique fingerprint.

Cite this