Lipopolysaccharide transport and assembly at the outer membrane: The PEZ model

Suguru Okuda, David J. Sherman, Thomas J. Silhavy, Natividad Ruiz, Daniel Kahne

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations

Abstract

Gram-negative bacteria have a double-membrane cellular envelope that enables them to colonize harsh environments and prevents the entry of many clinically available antibiotics. A main component of most outer membranes is lipopolysaccharide (LPS), a glycolipid containing several fatty acyl chains and up to hundreds of sugars that is synthesized in the cytoplasm. In the past two decades, the proteins that are responsible for transporting LPS across the cellular envelope and assembling it at the cell surface in Escherichia coli have been identified, but it remains unclear how they function. In this Review, we discuss recent advances in this area and present a model that explains how energy from the cytoplasm is used to power LPS transport across the cellular envelope to the cell surface.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalNature Reviews Microbiology
Volume14
Issue number6
DOIs
StatePublished - Jun 1 2016

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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