Linking structure and function: biological insights from fly connectomes

Albert Lin; Mala Murthy

doi:10.1038/s41592-025-02949-z

Linking structure and function: biological insights from fly connectomes

Albert Lin
, Mala Murthy

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Detailed maps, or connectomes, of the fly brain and nervous system reveal how circuit architecture (wiring) shapes both neural activity and behavior. These maps already demonstrate that it is possible to predict function from structure, and provide the essential foundation for biologically realistic models of circuit function.

Original language	English (US)
Pages (from-to)	2476-2478
Number of pages	3
Journal	Nature Methods
Volume	22
Issue number	12
DOIs	https://doi.org/10.1038/s41592-025-02949-z
State	Published - Dec 2025

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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10.1038/s41592-025-02949-z

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title = "Linking structure and function: biological insights from fly connectomes",

abstract = "Detailed maps, or connectomes, of the fly brain and nervous system reveal how circuit architecture (wiring) shapes both neural activity and behavior. These maps already demonstrate that it is possible to predict function from structure, and provide the essential foundation for biologically realistic models of circuit function.",

author = "Albert Lin and Mala Murthy",

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T2 - biological insights from fly connectomes

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AU - Murthy, Mala

N1 - Publisher Copyright: © Springer Nature America, Inc. 2025.

PY - 2025/12

Y1 - 2025/12

N2 - Detailed maps, or connectomes, of the fly brain and nervous system reveal how circuit architecture (wiring) shapes both neural activity and behavior. These maps already demonstrate that it is possible to predict function from structure, and provide the essential foundation for biologically realistic models of circuit function.

AB - Detailed maps, or connectomes, of the fly brain and nervous system reveal how circuit architecture (wiring) shapes both neural activity and behavior. These maps already demonstrate that it is possible to predict function from structure, and provide the essential foundation for biologically realistic models of circuit function.

UR - https://www.scopus.com/pages/publications/105024331968

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U2 - 10.1038/s41592-025-02949-z

DO - 10.1038/s41592-025-02949-z

M3 - Comment/debate

C2 - 41360952

AN - SCOPUS:105024331968

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SP - 2476

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JO - Nature Methods

JF - Nature Methods

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Linking structure and function: biological insights from fly connectomes

Abstract

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