@article{5891ffa7611f4f569ff401aa12a0b836,
title = "Linking a mutation to survival in wild mice",
abstract = "Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments in wild mice. We first directly estimate natural selection on pigmentation traits and an underlying pigment locus, Agouti, by using experimental enclosures of mice on different soil colors. Next, we show how a mutation in Agouti associated with survival causes lighter coat color through changes in its protein binding properties. Together, our findings demonstrate how a sequence variant alters phenotype and then reveal the ensuing ecological consequences that drive changes in population allele frequency, thereby illuminating the process of evolution by natural selection.",
author = "Barrett, {Rowan D.H.} and Stefan Laurent and Ricardo Mallarino and Pfeifer, {Susanne P.} and Xu, {Charles C.Y.} and Matthieu Foll and Kazumasa Wakamatsu and Duke-Cohan, {Jonathan S.} and Jensen, {Jeffrey D.} and Hoekstra, {Hopi E.}",
note = "Funding Information: We thank F. Baier, N. Bedford, A. Bendesky, J. Best, J. Chu, C. Clabaut, J. Gable, E. Hager, G. Hood, E. Jacobs-Palmer, E. Kay-Delaney, E. Kingsley, J. Kwon, M. Manceau, N. Man in{\textquoteright}t Veld, H. Metz, J.-M. Lassance, E. Lievens, C. Linnen, N. Rubinstein, L. Schmitt, H. Wegener, and I. Yen for field assistance; C. Clabaut, P. Muralidhar, and K. Turner for laboratory assistance; Z. Gompert, B. Peterson, and J.-M. Lassance for bioinformatics assistance; S. Badion for programming assistance; J. Demboski, B. Perrett, M. Perrett, B. Peterson, J. Ramos, L. Ramos, B. Ward, J. Wasserman, R. Wasserman, and the Denver Museum of Nature and Science for logistical support; L. M{\textquoteright}Gonigle for assistance with capture-recapture analysis; and J. Chupasko for curatorial assistance. We thank G. Barsh, J. Losos, P. Nosil, D. Petrov, D. Schluter, and T. Thurman for commenting on the manuscript. R.D.H.B. was supported by a Natural Sciences and Engineering Research Council of Canada Banting Postdoctoral Fellowship, a Foundational Questions in Evolutionary Biology Postdoctoral Fellowship, and a Canada Research Chair. C.C.Y.X. was supported by a Vanier Canada Graduate Scholarship from the Natural Sciences and Engineering Research Council of Canada. S.L., M.F., and R.M., as well as laboratory work, were supported by a Swiss National Science Foundation Sinergia grant to J.D.J, H.E.H., and L. Excoffier. Fieldwork was funded by the National Geographic Society, Putnam Expedition Grants from the Harvard Museum of Comparative Zoology (MCZ), and a Discovery Grant from the National Engineering and Research Council of Canada to R.D.H.B. H.E.H. is an Investigator of the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2019",
month = feb,
day = "1",
doi = "10.1126/science.aav3824",
language = "English (US)",
volume = "363",
pages = "499--504",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6426",
}