Lighting up mRNA localization in Drosophila oogenesis

Agata N. Becalska, Elizabeth R. Gavis

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in the Drosophila oocyte is essential for the development of the embryonic body axes. Fluorescent imaging methods are now being used to visualize these mRNAs in living tissue, allowing dynamic analysis of their behaviors throughout the process of localization. This review summarizes recent findings from such studies that provide new insight into the elaborate cellular mechanisms that are used to transport mRNAs to different regions of the oocyte and to maintain their localized distributions during oogenesis.

Original languageEnglish (US)
Pages (from-to)2493-2503
Number of pages11
JournalDevelopment
Volume136
Issue number15
DOIs
StatePublished - Aug 1 2009

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

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