Light-Driven Flavin-Based Biocatalysis

Daria Grosheva, Todd K. Hyster

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Light-driven biocatalysis has emerged as a powerful approach to unlock new enzymatic reactivity modes. In this field, flavoenzymes are particularly effective, owing to the presence of a redox-active cofactor that can act as a photocatalyst. The irradiation with visible light therefore enables new catalytic functions, which complement the natural reactivity repertoire of flavoenzymes. Herein, we provide a comprehensive review of native and promiscuous photoenzymatic activities of flavin-dependent proteins. In addition, flavoenzyme-based synergistic systems with an exogenous photoredox catalyst are discussed.

Original languageEnglish (US)
Title of host publicationFlavin-Based Catalysis
Subtitle of host publicationPrinciples and Applications
Number of pages21
ISBN (Electronic)9783527830138
ISBN (Print)9783527348343
StatePublished - Jan 1 2021

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Materials Science


  • biocatalysis
  • enzyme promiscuity
  • flavoenzymes
  • photoenzymes
  • photoredox catalysis


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