Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator

Evan W. Miller; Nicolas Taulet; Carl S. Onak; Elizabeth J. New; Julie K. Lanselle; Gillian S. Smelick; Christopher J. Chang

doi:10.1021/ja107783j

Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator

Evan W. Miller, Nicolas Taulet, Carl S. Onak, Elizabeth J. New, Julie K. Lanselle, Gillian S. Smelick, Christopher J. Chang

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Hydrogen peroxide (H₂O₂) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H ₂O₂ on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H₂O₂ as well as remote control of cell behavior via H₂O₂-mediated pathways.

Original language	English (US)
Pages (from-to)	17071-17073
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	48
DOIs	https://doi.org/10.1021/ja107783j
State	Published - Dec 8 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja107783j

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abstract = "Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H 2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.",

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AU - Miller, Evan W.

AU - Taulet, Nicolas

AU - Onak, Carl S.

AU - New, Elizabeth J.

AU - Lanselle, Julie K.

AU - Smelick, Gillian S.

AU - Chang, Christopher J.

PY - 2010/12/8

Y1 - 2010/12/8

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AB - Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H 2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.

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Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator

Abstract

All Science Journal Classification (ASJC) codes

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