Ligand trapping in epithelial layers and cell cultures

Alexander M. Berezhkovskii, Lazaros Batsilas, Stanislav Y. Shvartsman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We analyze a stochastic model that describes receptor-mediated ligand trapping in epithelial layers and cell culture assays. In both cases, the problem is reduced to diffusion of a Brownian particle between the partially absorbing and reflective surfaces. We derive an analytical expression for the spatial distribution of the trapping points and identify the domains of applicability of the two limiting regimes. We conclude that a thin layer approximation is applicable for ligand trapping in epithelial layers while a typical cell culture experiment is appropriately described within an infinite layer approximation.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalBiophysical Chemistry
Volume107
Issue number3
DOIs
StatePublished - Feb 15 2004

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

Keywords

  • Cell culture
  • Diffusion
  • Epithelial layer
  • Ligand
  • Receptor

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