@article{e3a5a8cdc21a4b508ebf83c0e959c98b,
title = "LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI",
abstract = "This paper shows that superparamagnetic iron oxide nanoparticles (SPIONs) conjugated to luteinizing hormone releasing hormone (LHRH) (LHRH-SPIONs), can be used to target breast cancer cells. They also act as contrast enhancement agents during the magnetic resonance imaging of breast cancer xenografts. A combination of transmission electron microscopy (TEM) and spectrophotometric analysis was used in our experiments, to investigate the specific accumulation of the functionalized superparamagnetic iron oxide nanoparticles (SPIONs) in cancer cells. The contrast enhancement of conventional T2 images obtained from the tumor tissue and of breast cancer xenograft bearing mice is shown to be much greater than that in saline controls, when the tissues were injected with LHRH-SPIONs. Magnetic anisotropy multi-CRAZED images of tissues extracted from mice injected with SPIONs were also found to have enhanced MRI contrast in breast cancer xenografts and metastases in the lungs.",
keywords = "Breast cancer detection, Magnetic nanoparticles, Receptor-mediated endocytosis",
author = "J. Meng and J. Fan and G. Galiana and Branca, {R. T.} and Clasen, {P. L.} and S. Ma and J. Zhou and C. Leuschner and Kumar, {C. S.S.R.} and J. Hormes and T. Otiti and Beye, {A. C.} and Harmer, {M. P.} and Kiely, {C. J.} and W. Warren and Haataja, {M. P.} and Soboyejo, {W. O.}",
note = "Funding Information: The TEM work and the T2 MRI research were supported by the Division of Materials Research of the National Science Foundation (DMR 0231418). The multi-CRAZED MRI work was also supported by NIH grant EB 02122 and the State of New Jersey. The authors would also like to thank the Pennington Biomedical Center and the Center for Advanced Microstructures and Devices (CK and JH) for financial support of the cancer biology and nanoparticle synthesis work. Dr. Carola Leuschner thanks PBRC/LSU for support of the project “Detection of disseminated cells and micrometastases by ligand conjugated superparamagnetic iron oxide nanoparticles”. Finally, the work at CAMD was supported financially by grants from NSF-EPSCoR ((2001–04) RII-03) and DARPA (Grant No: HR0011-04-C-0068). CJK and MPH would like to acknowledge the financial support of the NSF (Grant No. DMI-0304180 and Grant No. DMI-0457602) and the Pennsylvania Department of Community and Economic Development under contract # 20-906-0009. Prof Haataja would like to acknowledge support from NSF through NSF-DMR Grant No. 0449184 and the NSF-MRSEC Program, Grant No. DMR-0213706 at Princeton University. ",
year = "2009",
month = may,
day = "5",
doi = "10.1016/j.msec.2008.09.039",
language = "English (US)",
volume = "29",
pages = "1467--1479",
journal = "Materials Science and Engineering C",
issn = "0928-4931",
publisher = "Elsevier B.V.",
number = "4",
}