TY - JOUR
T1 - Lessons learned and paths forward for rabies dog vaccination in madagascar
T2 - A case study of pilot vaccination campaigns in moramanga district
AU - Filla, Caitlynn
AU - Rajeev, Malavika
AU - Randriana, Zoavina
AU - Hanitriniana, Chantal
AU - Rafaliarison, Radoniaina R.
AU - Edosoa, Glenn Torrencelli
AU - Andriamananjara, Mamitiana
AU - Razafindraibe, Nivohanitra P.
AU - Nely, José
AU - Ferreira, Angelique
AU - Yang, Annie L.
AU - Daniel, Fenomanana
AU - Clarke, Tara A.
AU - Farris, Zachary
AU - Stone, Terry
AU - Lastdrager, Jochem
AU - Rajaonarivelo, Tsiky
AU - Hampson, Katie
AU - Metcalf, C. Jessica E.
AU - Valenta, Kim
N1 - Funding Information:
Funding: The campaign costs were supported by donations from Lush Cosmetics Charity Pot. Parts of this work were funded by grants from the Center for Health and Wellbeing and the Department of Ecology and Evolutionary Biology at Princeton University to M.R. M.R. was supported by an NSF Graduate Research Fellowship and a Princeton Institute for Regional and International Studies Graduate Fellowship. K.H. is supported by the Wellcome Trust (207569/Z/17/Z).
Funding Information:
Acknowledgments: We thank all the veterinarians, livestock officers, local officials and leaders, NGO staff, and volunteers involved in each of the campaigns. We are grateful to the staff and officials at the Department of Veterinary Services, the Ministry of Public Health, and the Institut Pasteur de Madagascar for their support and technical assistance. In particular, we thank Carmen Barba Claassens, Jean Hyacinthe Randrianarisoa, Ranaivoarimanana, Fierenantsoa Randriamahatana, Esther Noiarisaona, Cara Brook, Christian Ranaivoson, Rila Ratovoson, and Claire LeBlanc. The campaign costs were supported by donations from Lush Cosmetics Charity Pot. Parts of this work were funded by grants from the Center for Health and Wellbeing and from the Department of Ecology and Evolutionary Biology at Princeton University to M.R. M.R. was supported by an NSF Graduate Research Fellowship and a Princeton Institute for Regional and International Studies Graduate Fellowship. K.H. was supported by the Wellcome Trust (207569/Z/17/Z). We want to particularly acknowledge the contributions to this work by Annie Li Yang, an undergraduate researcher and volunteer with Princeton University and the Mad Dog Initiative who tragically passed away in a car accident before this research was published.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/4/12
Y1 - 2021/4/12
N2 - Canine rabies causes an estimated 60,000 human deaths per year, but these deaths are preventable through post-exposure prophylaxis of people and vaccination of domestic dogs. Dog vaccination campaigns targeting 70% of the population are effective at interrupting transmission. Here, we report on lessons learned during pilot dog vaccination campaigns in the Moramanga District of Madagascar. We compare two different vaccination strategies: a volunteer-driven effort to vaccinate dogs in two communes using static point vaccination and continuous vaccination as part of routine veterinary services. We used dog age data from the campaigns to estimate key demographic parameters and to simulate different vaccination strategies. Overall, we found that dog vaccination was feasible and that most dogs were accessible to vaccination. The static-point campaign achieved higher coverage but required more resources and had a limited geographic scope compared to the continuous delivery campaign. Our modeling results suggest that targeting puppies through community-based vaccination efforts could improve coverage. We found that mass dog vaccination is feasible and can achieve high coverage in Madagascar; however, context-specific strategies and an investment in dog vaccination as a public good will be required to move the country towards elimination.
AB - Canine rabies causes an estimated 60,000 human deaths per year, but these deaths are preventable through post-exposure prophylaxis of people and vaccination of domestic dogs. Dog vaccination campaigns targeting 70% of the population are effective at interrupting transmission. Here, we report on lessons learned during pilot dog vaccination campaigns in the Moramanga District of Madagascar. We compare two different vaccination strategies: a volunteer-driven effort to vaccinate dogs in two communes using static point vaccination and continuous vaccination as part of routine veterinary services. We used dog age data from the campaigns to estimate key demographic parameters and to simulate different vaccination strategies. Overall, we found that dog vaccination was feasible and that most dogs were accessible to vaccination. The static-point campaign achieved higher coverage but required more resources and had a limited geographic scope compared to the continuous delivery campaign. Our modeling results suggest that targeting puppies through community-based vaccination efforts could improve coverage. We found that mass dog vaccination is feasible and can achieve high coverage in Madagascar; however, context-specific strategies and an investment in dog vaccination as a public good will be required to move the country towards elimination.
KW - Canine rabies
KW - Central point vaccination
KW - Mass dog vaccination
KW - Puppy vaccination
KW - Zeroby30
UR - http://www.scopus.com/inward/record.url?scp=85106874001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106874001&partnerID=8YFLogxK
U2 - 10.3390/tropicalmed6020048
DO - 10.3390/tropicalmed6020048
M3 - Article
C2 - 33921499
AN - SCOPUS:85106874001
SN - 2414-6366
VL - 6
JO - Tropical Medicine and Infectious Disease
JF - Tropical Medicine and Infectious Disease
IS - 2
M1 - 48
ER -