Abstract
MAVEN is an open-source software program for interactive processing of LC-MS-based metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple reaction monitoring data or high-resolution full-scan mass spectrometry data. It automatically detects and reports peak intensities for isotope-labeled metabolites. Menu-driven, click-based navigation allows visualization of raw and analyzed data. Here we provide a User Guide for MAVEN. Step-by-step instructions are provided for data import, peak alignment across samples, identification of metabolites that differ strongly between biological conditions, quantitation and visualization of isotope-labeling patterns, and export of tables of metabolite-specific peak intensities. Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis.
| Original language | English (US) |
|---|---|
| Article number | 14.11 |
| Journal | Current Protocols in Bioinformatics |
| Issue number | SUPPL.37 |
| DOIs | |
| State | Published - Mar 2012 |
All Science Journal Classification (ASJC) codes
- Structural Biology
- Biochemistry
Keywords
- Kinetic flux profiling
- Liquid chromatography-mass spectrometry
- Metabolic flux analysis
- Metabolomics
- Pathway visualization and mapping
- Stable isotope labeling
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