Latent versus productive infection: The alpha herpesvirus switch

Orkide O. Koyuncu, Margaret A. Macgibeny, Lynn W. Enquist

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Alpha herpesviruses are common pathogens of mammals. They establish a productive infection in many cell types, but a life-long latent infection occurs in PNS neurons. A vast majority of the human population has latent HSV-1 infections. Currently, there is no cure to clear latent infections. Even though HSV-1 is among the best studied viral pathogens, regulation of latency and reactivation is not well understood due to several challenges including a lack of animal models that precisely recapitulate latency/reactivation episodes; a difficulty in modeling in vitro latency; and a limited understanding of neuronal biology. In this review, we discuss insights gained from in vitro latency models with a focus on the neuronal and viral factors that determine the mode of infection.

Original languageEnglish (US)
Pages (from-to)431-443
Number of pages13
JournalFuture Virology
Issue number6
StatePublished - 2018

All Science Journal Classification (ASJC) codes

  • Virology


  • alpha herpesviruses
  • in vitro latency model
  • latency
  • reactivation


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