Lasso peptides: Structure, function, biosynthesis, and engineering

Mikhail O. Maksimov, Si Jia Pan, A. James Link

Research output: Contribution to journalReview articlepeer-review

190 Scopus citations


Covering: up to May 2012 Lasso peptides are a class of ribosomally- synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers our current knowledge about the biosynthesis of those molecules. The isolation and characterization of lasso peptides are also covered as are bioinformatics strategies for the discovery of new lasso peptides from genomic sequence data. Several studies on the engineering of new or improved function into lasso peptides are highlighted, and unanswered questions in the field are also described.

Original languageEnglish (US)
Pages (from-to)996-1006
Number of pages11
JournalNatural Product Reports
Issue number9
StatePublished - Sep 2012

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Biochemistry
  • Organic Chemistry


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