TY - JOUR
T1 - Large-scale resculpting of cortical circuits in children after surgical resection
AU - Maallo, Anne Margarette S.
AU - Granovetter, Michael C.
AU - Freud, Erez
AU - Kastner, Sabine
AU - Pinsk, Mark A.
AU - Patterson, Christina
AU - Behrmann, Marlene
N1 - Funding Information:
The authors would like to thank the participants and their families for taking part in this study. We also would like to thank Dr Daniel Glen for his help in implementing individual subject volumetric image registration to the HCP atlas, Ms Jennifer Monahan of Children’s Hospital for assistance in patient recruitment, and Mr Scott Kurdilla and Mr Mark Vignone for assistance in scanning the participants. We also thank Dr Avital Hahamy and Dr David Plaut for useful suggestions and conversations. This research was supported by a grant from the National Eye Institute (NIH) RO1 EY0207018 to MP and CP and a Grant from the National Institute of General Medical Sciences (NIH) T32 GM081760 to MCG. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Eye Institute, National Institute of General Medical Sciences, or the National Institutes of Health.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.
AB - Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.
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U2 - 10.1038/s41598-020-78394-z
DO - 10.1038/s41598-020-78394-z
M3 - Article
C2 - 33299002
AN - SCOPUS:85097314385
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 21589
ER -