Large-scale neural recordings call for new insights to link brain and behavior

Anne E. Urai, Brent Doiron, Andrew M. Leifer, Anne K. Churchland

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. In the present review, we first describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to characterize behavior in the context of such measurements. We next highlight insights obtained from large-scale neural recordings in diverse model systems, and argue that some of these pose a challenge to traditional theoretical frameworks. Finally, we elaborate on existing modeling frameworks to interpret these data, and argue that the interpretation of brain-wide neural recordings calls for new theoretical approaches that may depend on the desired level of understanding. These advances in both neural recordings and theory development will pave the way for critical advances in our understanding of the brain.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalNature neuroscience
Issue number1
StatePublished - Jan 2022

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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