Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells

Alexander R. Lippert; Tina Gschneidtner; Christopher J. Chang

doi:10.1039/c0cc01560a

Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells

Alexander R. Lippert, Tina Gschneidtner, Christopher J. Chang

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Lanthanide-based luminescent probes TPR1 and TPR2 were developed for the detection of hydrogen peroxide (H₂O₂) in living systems. The chemoselective reaction of these boronate-protected probes with H ₂O₂ resulted in an enhanced lanthanide sensitization and a 6-fold increase in luminescent intensity. TPR2 was utilized to measure the endogenous production of H₂O₂ in RAW 264.7 macrophages using time-gated luminescent spectroscopy.

Original language	English (US)
Pages (from-to)	7510-7512
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	40
DOIs	https://doi.org/10.1039/c0cc01560a
State	Published - Oct 28 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Lanthanide-based luminescent probes TPR1 and TPR2 were developed for the detection of hydrogen peroxide (H2O2) in living systems. The chemoselective reaction of these boronate-protected probes with H 2O2 resulted in an enhanced lanthanide sensitization and a 6-fold increase in luminescent intensity. TPR2 was utilized to measure the endogenous production of H2O2 in RAW 264.7 macrophages using time-gated luminescent spectroscopy.",

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AU - Chang, Christopher J.

PY - 2010/10/28

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AB - Lanthanide-based luminescent probes TPR1 and TPR2 were developed for the detection of hydrogen peroxide (H2O2) in living systems. The chemoselective reaction of these boronate-protected probes with H 2O2 resulted in an enhanced lanthanide sensitization and a 6-fold increase in luminescent intensity. TPR2 was utilized to measure the endogenous production of H2O2 in RAW 264.7 macrophages using time-gated luminescent spectroscopy.

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Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells

Abstract

All Science Journal Classification (ASJC) codes

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