Lamin post-translational modifications: emerging toggles of nuclear organization and function

Laura A. Murray-Nerger, Ileana M. Cristea

Research output: Contribution to journalReview articlepeer-review

Abstract

Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite these numerous roles, an outstanding question has been how lamins are regulated. Accumulating work indicates that a range of lamin post-translational modifications (PTMs) control their functions both in homeostatic cells and in disease states such as progeria, muscular dystrophy, and viral infection. Here, we review the current knowledge of the diverse types of PTMs that regulate lamins in a site-specific manner. We highlight methods that can be used to characterize lamin PTMs whose functions are currently unknown and provide a perspective on the future of the lamin PTM field.

Original languageEnglish (US)
Pages (from-to)832-847
Number of pages16
JournalTrends in Biochemical Sciences
Volume46
Issue number10
DOIs
StatePublished - Oct 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Keywords

  • PTMs
  • acetylation
  • farnesylation
  • lamins
  • phosphorylation
  • ubiquitination

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