Kinetically assembled nanoparticles of bioactive macromolecules exhibit enhanced stability and cell-targeted biological efficacy

Adam W. York, Kyle R. Zablocki, Daniel R. Lewis, Li Gu, Kathryn E. Uhrich, Robert K. Prud'Homme, Prabhas V. Moghe

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.

Original languageEnglish (US)
Pages (from-to)733-739
Number of pages7
JournalAdvanced Materials
Volume24
Issue number6
DOIs
StatePublished - Feb 7 2012

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Keywords

  • atherosclerosis
  • cardiovascular disease
  • flash nanoprecipitation
  • macrophages
  • nanomedicine

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