Kinetically assembled nanoparticles of bioactive macromolecules exhibit enhanced stability and cell-targeted biological efficacy

Adam W. York; Kyle R. Zablocki; Daniel R. Lewis; Li Gu; Kathryn E. Uhrich; Robert K. Prud'Homme; Prabhas V. Moghe

doi:10.1002/adma.201103348

Kinetically assembled nanoparticles of bioactive macromolecules exhibit enhanced stability and cell-targeted biological efficacy

Adam W. York, Kyle R. Zablocki, Daniel R. Lewis, Li Gu, Kathryn E. Uhrich, Robert K. Prud'Homme, Prabhas V. Moghe

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.

Original language	English (US)
Pages (from-to)	733-739
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	6
DOIs	https://doi.org/10.1002/adma.201103348
State	Published - Feb 7 2012

All Science Journal Classification (ASJC) codes

Mechanics of Materials
Mechanical Engineering
General Materials Science

Keywords

atherosclerosis
cardiovascular disease
flash nanoprecipitation
macrophages
nanomedicine

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10.1002/adma.201103348

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abstract = "Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.",

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AU - Zablocki, Kyle R.

AU - Lewis, Daniel R.

AU - Gu, Li

AU - Uhrich, Kathryn E.

AU - Prud'Homme, Robert K.

AU - Moghe, Prabhas V.

PY - 2012/2/7

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AB - Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.

KW - atherosclerosis

KW - cardiovascular disease

KW - flash nanoprecipitation

KW - macrophages

KW - nanomedicine

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Kinetically assembled nanoparticles of bioactive macromolecules exhibit enhanced stability and cell-targeted biological efficacy

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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