Junctions as organizing centers in epithelial cells? A fly perspective

Thomas Lecuit; Eric Wieschaus

doi:10.1034/j.1600-0854.2002.030202.x

Junctions as organizing centers in epithelial cells? A fly perspective

Thomas Lecuit, Eric Wieschaus

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.

Original language	English (US)
Pages (from-to)	92-97
Number of pages	6
Journal	Traffic
Volume	3
Issue number	2
DOIs	https://doi.org/10.1034/j.1600-0854.2002.030202.x
State	Published - 2002

All Science Journal Classification (ASJC) codes

Genetics
Molecular Biology
Structural Biology
Biochemistry
Cell Biology

Keywords

Asymmetric cell division
Cellularization
Drosophila
Junctions
Membrane growth
Polarity

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10.1034/j.1600-0854.2002.030202.x

Cite this

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abstract = "Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.",

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AU - Lecuit, Thomas

AU - Wieschaus, Eric

PY - 2002

Y1 - 2002

N2 - Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.

AB - Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.

KW - Asymmetric cell division

KW - Cellularization

KW - Drosophila

KW - Junctions

KW - Membrane growth

KW - Polarity

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DO - 10.1034/j.1600-0854.2002.030202.x

M3 - Review article

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ER -

Junctions as organizing centers in epithelial cells? A fly perspective

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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