Junctions as organizing centers in epithelial cells? A fly perspective

Thomas Lecuit, Eric Wieschaus

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalTraffic
Volume3
Issue number2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • Asymmetric cell division
  • Cellularization
  • Drosophila
  • Junctions
  • Membrane growth
  • Polarity

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