Joint associations of blood plasma proteins with overwinter survival of a large mammal

Romain Garnier, Christopher K. Cheung, Kathryn A. Watt, Jill G. Pilkington, Josephine M. Pemberton, Andrea Linn Graham

Research output: Contribution to journalLetter

8 Scopus citations

Abstract

In many wild animal populations, hosts are at risk of parasites and malnutrition and resource costs of defence may be difficult to afford. We postulate that proteins, important in homeostasis and immunity, play a complex but central role in condition dependence and resource costs of mammalian immune defence. To test this, we measured plasma concentrations of albumin, total proteins. Self-reactive antibodies and parasite-specific IgG in female Soay sheep. Using a principal component analysis, we found a new metric of condition reflecting individual variation in acquisition, assimilation and/or recycling of plasma proteins that predicted overwinter survival. Controlling for this metric, an age-dependent trade-off between antibody titres and protein reserves emerged, indicating costs of mounting an antibody response: younger individuals survived best when prioritising immunity while older individuals fared better when maintaining high-protein nutritional plane. These findings suggest fascinating roles for protein acquisition and allocation in influencing survival in wild animal populations.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalEcology letters
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2017

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

Keywords

  • Disease ecology
  • Ovis aries
  • ecological immunology
  • nutritional ecology

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    Garnier, R., Cheung, C. K., Watt, K. A., Pilkington, J. G., Pemberton, J. M., & Graham, A. L. (2017). Joint associations of blood plasma proteins with overwinter survival of a large mammal. Ecology letters, 20(2), 175-183. https://doi.org/10.1111/ele.12719