Irreversible assembly of membrane fusion machines

Doug Barrick, Frederick M. Hughson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A large kinetic barrier prevents spontaneous disassembly of SNARE complexes, complicating thermodynamic measurements and resulting in hysteresis. Nonetheless, this kinetic barrier is probably crucial for SNARE function.

Original languageEnglish (US)
Pages (from-to)78-80
Number of pages3
JournalNature Structural Biology
Issue number2
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Genetics
  • Structural Biology
  • Biochemistry


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