Investigation of coumarin functionality on the formation of polymeric nanoparticles

Jae Woo Chung, Colin Neikirk, Rodney D. Priestley

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalJournal of Colloid And Interface Science
Volume396
DOIs
StatePublished - Feb 26 2013

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Keywords

  • Coumarin
  • Dynamic light scattering (DLS)
  • Flash nanoprecipitation
  • Nanoparticles
  • Poly(methyl methacrylate)
  • Zeta-potential

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