Investigation of coumarin functionality on the formation of polymeric nanoparticles

Jae Woo Chung; Colin Neikirk; Rodney D. Priestley

doi:10.1016/j.jcis.2013.01.038

Investigation of coumarin functionality on the formation of polymeric nanoparticles

Jae Woo Chung, Colin Neikirk, Rodney D. Priestley

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.

Original language	English (US)
Pages (from-to)	16-22
Number of pages	7
Journal	Journal of Colloid And Interface Science
Volume	396
DOIs	https://doi.org/10.1016/j.jcis.2013.01.038
State	Published - Feb 26 2013

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

Keywords

Coumarin
Dynamic light scattering (DLS)
Flash nanoprecipitation
Nanoparticles
Poly(methyl methacrylate)
Zeta-potential

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10.1016/j.jcis.2013.01.038

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title = "Investigation of coumarin functionality on the formation of polymeric nanoparticles",

abstract = "The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.",

keywords = "Coumarin, Dynamic light scattering (DLS), Flash nanoprecipitation, Nanoparticles, Poly(methyl methacrylate), Zeta-potential",

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AU - Chung, Jae Woo

AU - Neikirk, Colin

AU - Priestley, Rodney D.

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N2 - The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.

AB - The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.

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KW - Nanoparticles

KW - Poly(methyl methacrylate)

KW - Zeta-potential

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