TY - JOUR
T1 - Investigation of coumarin functionality on the formation of polymeric nanoparticles
AU - Chung, Jae Woo
AU - Neikirk, Colin
AU - Priestley, Rodney D.
N1 - Funding Information:
We acknowledge usage of the PRISM Imaging and Analysis Center, which is supported in part by the NSF MRSEC program through the Princeton Center for Complex Materials (DMR-0819860). R.D.P. acknowledge the donors of the American Chemical Society Petroleum Research Fund for partial support of this work (PRF 49903-DNI10) and the 3M-nontenured faculty grant program for partial support of this work. We also acknowledge the Korea Institute of Science and Technology (KIST) Institutional program. We thank R.K. Prud’homme for the use of DLS equipment.
PY - 2013
Y1 - 2013
N2 - The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.
AB - The effect of coumarin molecules on the formation of polymeric nanoparticles is examined using a model polymer, poly(methyl methacrylate) (PMMA), functionalized with varying amounts of coumarin pendant groups (PCM). PCM nanoparticles are prepared in a continuous manner by Flash NanoPrecipitation (FNP). PCM forms spherical nanoparticles in water, while the PMMA without coumarin functionality fails to form nanoparticles. As the amount of coumarin functionality increases, the nanoparticle size and size polydispersity are decreased and the nanoparticle stability in water is enhanced. In particular, well-isolated spherical nanoparticles are generated from PCM with 20. mol% coumarin side chain functionality. These results can be explained by an observed increase in the negative surface charge with increasing coumarin content in the polymer.
KW - Coumarin
KW - Dynamic light scattering (DLS)
KW - Flash nanoprecipitation
KW - Nanoparticles
KW - Poly(methyl methacrylate)
KW - Zeta-potential
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U2 - 10.1016/j.jcis.2013.01.038
DO - 10.1016/j.jcis.2013.01.038
M3 - Article
C2 - 23465184
AN - SCOPUS:84875448022
SN - 0021-9797
VL - 396
SP - 16
EP - 22
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
ER -