Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging

S. Ogawa, D. W. Tank, R. Menon, J. M. Ellermann, S. G. Kim, H. Merkle, K. Ugurbil

Research output: Contribution to journalArticle

2643 Scopus citations

Abstract

We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T2/(*). The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous- blood oxygenation.

Original languageEnglish (US)
Pages (from-to)5951-5955
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number13
DOIs
StatePublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • blood oxygenation
  • cerebral blood flow
  • magnetic susceptibility
  • positron emission tomography
  • visual cortex

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