Intrinsic neuronal dynamics predict distinct functional roles during working memory

D. F. Wasmuht, E. Spaak, T. J. Buschman, E. K. Miller, M. G. Stokes

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Working memory (WM) is characterized by the ability to maintain stable representations over time; however, neural activity associated with WM maintenance can be highly dynamic. We explore whether complex population coding dynamics during WM relate to the intrinsic temporal properties of single neurons in lateral prefrontal cortex (lPFC), the frontal eye fields (FEF), and lateral intraparietal cortex (LIP) of two monkeys (Macaca mulatta). We find that cells with short timescales carry memory information relatively early during memory encoding in lPFC; whereas long-timescale cells play a greater role later during processing, dominating coding in the delay period. We also observe a link between functional connectivity at rest and the intrinsic timescale in FEF and LIP. Our results indicate that individual differences in the temporal processing capacity predict complex neuronal dynamics during WM, ranging from rapid dynamic encoding of stimuli to slower, but stable, maintenance of mnemonic information.

Original languageEnglish (US)
Article number3499
JournalNature communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Intrinsic neuronal dynamics predict distinct functional roles during working memory'. Together they form a unique fingerprint.

  • Cite this

    Wasmuht, D. F., Spaak, E., Buschman, T. J., Miller, E. K., & Stokes, M. G. (2018). Intrinsic neuronal dynamics predict distinct functional roles during working memory. Nature communications, 9(1), [3499]. https://doi.org/10.1038/s41467-018-05961-4