Intrinsic and innate defenses of neurons: Détente with the herpesviruses

Lynn W. Enquist, David A. Leib

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.

Original languageEnglish (US)
Article numbere01200-16
JournalJournal of virology
Volume91
Issue number1
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Keywords

  • Herpesviruses
  • Innate immunity
  • Intrinsic immunity
  • Neuroimmunology
  • Neurotropic viruses

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