Intricate roles of mammalian sirtuins in defense against viral pathogens

Hanna G. Budayeva, Elizabeth A. Rowland, Ileana M. Cristea

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalJournal of virology
Issue number1
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Insect Science
  • Virology
  • Microbiology
  • Immunology


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