Intramolecular rearrangements as a consequence of the dephosphorylation of phosphoaspartate residues in proteins

Scott Napper, Peter M. Wolanin, Daniel J. Webre, Jason Kindrachuk, Bruce Waygood, Jeffry Benton Stock

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Aspartate phosphorylation induces changes in protein conformation that are used to regulate processes ranging from gene expression and cell differentiation to cell motility and the generation of electrochemical gradients across membranes. We show here that dephosphorylation of the phosphoaspartate in the chemotaxis response regulator CheY can result in the loss of a water molecule that may be due to formation of a succinimide intermediate.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalFEBS Letters
Volume538
Issue number1-3
DOIs
StatePublished - Mar 13 2003

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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