Intragenic amplification and divergence in the mouse α-fetoprotein gene

Fern Alexander Eiferman, Peter R. Young, Richard W. Scott, Shirley M. Tilghman

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Abstract

The DNA sequences of the 14 exon junctions in the murine α-fetoprotein gene were determined using cloned genomic DNA. When these exons were examined with respect to the polypeptide segments they encoded, a direct correspondence between a threefold repeat of four exons and three protein domains was observed. Nucleotide sequence comparisons among the four exons of each domain were used to deduce the likely structure of the primordial domain, and the order and mechanism of its triplication to form the tripartite ancestral gene from which both α-fetoprotein and serum albumin arose. Sequence homologies among the four exons that constitute a single domain also suggest that they were derived, at least in part, from a common sequence which underwent successive amplification and divergence.

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalNature
Volume294
Issue number5843
DOIs
StatePublished - Dec 1 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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    Eiferman, F. A., Young, P. R., Scott, R. W., & Tilghman, S. M. (1981). Intragenic amplification and divergence in the mouse α-fetoprotein gene. Nature, 294(5843), 713-718. https://doi.org/10.1038/294713a0