Interplay between hormonal and mechanical signals in mammary morphodynamics

Alişya A. Anlaş, Celeste M. Nelson

Research output: Contribution to journalShort surveypeer-review


Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.

Original languageEnglish (US)
Pages (from-to)434-436
Number of pages3
JournalTrends in Cell Biology
Issue number6
StatePublished - Jun 2024

All Science Journal Classification (ASJC) codes

  • Cell Biology


  • mechanical force
  • mechanical stress
  • mechanobiology
  • tissue morphogenesis


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