Interplay between hormonal and mechanical signals in mammary morphodynamics

Alişya A. Anlaş; Celeste M. Nelson

doi:10.1016/j.tcb.2024.03.004

Interplay between hormonal and mechanical signals in mammary morphodynamics

Research output: Contribution to journal › Short survey › peer-review

Abstract

Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.

Original language	English (US)
Pages (from-to)	434-436
Number of pages	3
Journal	Trends in Cell Biology
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/j.tcb.2024.03.004
State	Published - Jun 2024

All Science Journal Classification (ASJC) codes

Cell Biology

Keywords

mechanical force
mechanical stress
mechanobiology
tissue morphogenesis

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10.1016/j.tcb.2024.03.004

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title = "Interplay between hormonal and mechanical signals in mammary morphodynamics",

abstract = "Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.",

keywords = "mechanical force, mechanical stress, mechanobiology, tissue morphogenesis",

author = "Anla{\c s}, {Ali{\c s}ya A.} and Nelson, {Celeste M.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = jun,

doi = "10.1016/j.tcb.2024.03.004",

language = "English (US)",

volume = "34",

pages = "434--436",

journal = "Trends in Cell Biology",

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T1 - Interplay between hormonal and mechanical signals in mammary morphodynamics

AU - Anlaş, Alişya A.

AU - Nelson, Celeste M.

PY - 2024/6

Y1 - 2024/6

N2 - Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.

AB - Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.

KW - mechanical force

KW - mechanical stress

KW - mechanobiology

KW - tissue morphogenesis

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U2 - 10.1016/j.tcb.2024.03.004

DO - 10.1016/j.tcb.2024.03.004

M3 - Short survey

C2 - 38538440

AN - SCOPUS:85189005675

SN - 0962-8924

VL - 34

SP - 434

EP - 436

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 6

ER -

Interplay between hormonal and mechanical signals in mammary morphodynamics

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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