Abstract
Telomeric position effect (TPE) refers to the ability of telomeres to repress the transcription of genes in their vicinity. Internal stretches of C1-3A DNA, the sequence found at Saccharomyces telomeres, also repressed transcription of nearby genes. This repression, hereafter called C1-3A- based silencing, was observed at several chromosomal loci, including on a circular chromosome. The magnitude of C1-3A-based silencing was increased by both proximity to a telomere and increased length of the C1-3A tracts. C1-3A-based silencing was affected by many of the same genes and conditions that influence TPE and acted in an orientation-independent manner. Thus, in yeast, an expanded array of a simple repetitive DNA, C1-3A, is sufficient to promote the assembly of a transcriptionally silent chromosomal domain.
Original language | English (US) |
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Pages (from-to) | 1411-1422 |
Number of pages | 12 |
Journal | Genes and Development |
Volume | 8 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 1994 |
All Science Journal Classification (ASJC) codes
- Genetics
- Developmental Biology
Keywords
- Telomeres
- position effect
- silencers
- yeast