Internal promoter elements of transfer RNA genes are preferentially exposed in chromatin

Robert DeLotto; Paul Schedl

doi:10.1016/0022-2836(84)90158-X

Internal promoter elements of transfer RNA genes are preferentially exposed in chromatin

Robert DeLotto
, Paul Schedl

Molecular Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have examined the chromatin organization of a cluster of transfer RNA genes at the cytogenic locus 90BC on the right arm of the third Drosophila melanogaster chromosome. We find that the internal promoter sequences are preferentially exposed to micrococcal nuclease and DNase I in chromatin. Moreover, these exposed sequences have an unusual single strand nuclease-sensitive conformation.

Original language	English (US)
Pages (from-to)	607-628
Number of pages	22
Journal	Journal of Molecular Biology
Volume	179
Issue number	4
DOIs	https://doi.org/10.1016/0022-2836(84)90158-X
State	Published - Nov 15 1984

All Science Journal Classification (ASJC) codes

Molecular Biology
Structural Biology

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10.1016/0022-2836(84)90158-X

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@article{03f5193078f44dafac77cde0c9b04cda,

title = "Internal promoter elements of transfer RNA genes are preferentially exposed in chromatin",

abstract = "We have examined the chromatin organization of a cluster of transfer RNA genes at the cytogenic locus 90BC on the right arm of the third Drosophila melanogaster chromosome. We find that the internal promoter sequences are preferentially exposed to micrococcal nuclease and DNase I in chromatin. Moreover, these exposed sequences have an unusual single strand nuclease-sensitive conformation.",

author = "Robert DeLotto and Paul Schedl",

note = "Funding Information: Wr thank 8. Han and L. Nguyen for excellent terhnical assistance and K. O{\textquoteleft}Hara for typing the manuscript. We would especially like t{\textquoteright}o thank Dr A. Udvardy for stimulating discussion and advice during thr course of this work. Support was provided by research grant,s from the American Cancer Society and the National Institutes of Health. We also thank the March of Dimes Birth Defect FoundaCon for funds from their research grant program. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1984",

month = nov,

day = "15",

doi = "10.1016/0022-2836(84)90158-X",

language = "English (US)",

volume = "179",

pages = "607--628",

journal = "Journal of Molecular Biology",

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T1 - Internal promoter elements of transfer RNA genes are preferentially exposed in chromatin

AU - DeLotto, Robert

AU - Schedl, Paul

N1 - Funding Information: Wr thank 8. Han and L. Nguyen for excellent terhnical assistance and K. O‘Hara for typing the manuscript. We would especially like t’o thank Dr A. Udvardy for stimulating discussion and advice during thr course of this work. Support was provided by research grant,s from the American Cancer Society and the National Institutes of Health. We also thank the March of Dimes Birth Defect FoundaCon for funds from their research grant program. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1984/11/15

Y1 - 1984/11/15

N2 - We have examined the chromatin organization of a cluster of transfer RNA genes at the cytogenic locus 90BC on the right arm of the third Drosophila melanogaster chromosome. We find that the internal promoter sequences are preferentially exposed to micrococcal nuclease and DNase I in chromatin. Moreover, these exposed sequences have an unusual single strand nuclease-sensitive conformation.

AB - We have examined the chromatin organization of a cluster of transfer RNA genes at the cytogenic locus 90BC on the right arm of the third Drosophila melanogaster chromosome. We find that the internal promoter sequences are preferentially exposed to micrococcal nuclease and DNase I in chromatin. Moreover, these exposed sequences have an unusual single strand nuclease-sensitive conformation.

UR - https://www.scopus.com/pages/publications/0021746948

UR - https://www.scopus.com/pages/publications/0021746948#tab=citedBy

U2 - 10.1016/0022-2836(84)90158-X

DO - 10.1016/0022-2836(84)90158-X

M3 - Article

C2 - 6094830

AN - SCOPUS:0021746948

SN - 0022-2836

VL - 179

SP - 607

EP - 628

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 4

ER -

Internal promoter elements of transfer RNA genes are preferentially exposed in chromatin

Abstract

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