Intercellular Communication, the Tumor Microenvironment, and Tumor Progression

Celeste M. Nelson; Mei Fong Pang

doi:10.1007/978-94-017-7380-5_13

Intercellular Communication, the Tumor Microenvironment, and Tumor Progression

Celeste M. Nelson, Mei Fong Pang

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct the growth, migration, and dissemination of cancer cells. Approaches that disrupt or coopt intercellular communication between the tumor and its host are exciting and potentially powerful anti-cancer therapeutic strategies.

Original language	English (US)
Title of host publication	Intercellular Communication In Cancer
Publisher	Springer Netherlands
Pages	343-362
Number of pages	20
ISBN (Electronic)	9789401773805
ISBN (Print)	9789401773799
DOIs	https://doi.org/10.1007/978-94-017-7380-5_13
State	Published - Jan 1 2015

All Science Journal Classification (ASJC) codes

General Medicine
General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

Keywords

Metastasis
Microenvironment
Stroma

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10.1007/978-94-017-7380-5_13

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AU - Pang, Mei Fong

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Y1 - 2015/1/1

N2 - Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct the growth, migration, and dissemination of cancer cells. Approaches that disrupt or coopt intercellular communication between the tumor and its host are exciting and potentially powerful anti-cancer therapeutic strategies.

AB - Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct the growth, migration, and dissemination of cancer cells. Approaches that disrupt or coopt intercellular communication between the tumor and its host are exciting and potentially powerful anti-cancer therapeutic strategies.

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KW - Microenvironment

KW - Stroma

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SP - 343

EP - 362

BT - Intercellular Communication In Cancer

PB - Springer Netherlands

ER -

Intercellular Communication, the Tumor Microenvironment, and Tumor Progression

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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