Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

Krystal K. Lum, Bokai Song, Joel D. Federspiel, Benjamin A. Diner, Timothy Howard, Ileana M. Cristea

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Lum et al. characterize the global protein interactome of the DNA sensor, cGAS, in cellular homeostasis and during HSV-1 infection. Integrating quantitative proteomics, CRISPR-Cas9 technology, reciprocal isolations, and cytokine assays, the function of the discovered cGAS-OASL interaction suggests negative interferon regulation and crosstalk between the DNA and RNA sensing pathways.

Original languageEnglish (US)
Pages (from-to)627-642.e6
JournalCell Systems
Volume7
Issue number6
DOIs
StatePublished - Dec 26 2018

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Keywords

  • DNA sensing
  • HSV-1
  • cGAS
  • herpesvirus
  • immune signaling
  • innate immunity
  • interactome
  • mass spectrometry
  • protein interactions
  • proteomics

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