@article{b5bfea910a7d4f198b57dd7210b0aa00,
title = "Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS",
abstract = "Lum et al. characterize the global protein interactome of the DNA sensor, cGAS, in cellular homeostasis and during HSV-1 infection. Integrating quantitative proteomics, CRISPR-Cas9 technology, reciprocal isolations, and cytokine assays, the function of the discovered cGAS-OASL interaction suggests negative interferon regulation and crosstalk between the DNA and RNA sensing pathways.",
keywords = "DNA sensing, HSV-1, cGAS, herpesvirus, immune signaling, innate immunity, interactome, mass spectrometry, protein interactions, proteomics",
author = "Lum, {Krystal K.} and Bokai Song and Federspiel, {Joel D.} and Diner, {Benjamin A.} and Timothy Howard and Cristea, {Ileana M.}",
note = "Funding Information: We thank Dr. Todd Greco for MS analysis assistance. Funding was provided by NIH NIGMS grant GM114141 and by the Edward Mallinckrodt Foundation to I.M.C., NIH fellowship F31GM120936 to K.K.L., CSC scholarship 201506210052 to B.S., and AHA fellowship 14PRE18890044 to B.A.D. Funding Information: We thank Dr. Todd Greco for MS analysis assistance. Funding was provided by NIH NIGMS grant GM114141 and by the Edward Mallinckrodt Foundation to I.M.C., NIH fellowship F31GM120936 to K.K.L., CSC scholarship 201506210052 to B.S., and AHA fellowship 14PRE18890044 to B.A.D. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = dec,
day = "26",
doi = "10.1016/j.cels.2018.10.010",
language = "English (US)",
volume = "7",
pages = "627--642.e6",
journal = "Cell Systems",
issn = "2405-4712",
publisher = "Cell Press",
number = "6",
}