Interaction of short-range repressors with Drosophila CtBP in the embryo

Yutaka Nibu, Hailan Zhang, Michael Levine

Research output: Contribution to journalArticle

214 Scopus citations

Abstract

Human CtBP attenuates transcriptional activation and tumorigenesis mediated by the adenovirus E1A protein. The E1A sequence motif that interacts with CtBP, Pro-X-Asp-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range repressors in Drosophila, Knirps and Snail, and is essential for the interaction of these proteins with Drosophila CtBP (dCtBP). A P-element-induced mutation in dCtBP exhibits gene-dosage interactions with a null mutation in knirps, which is consistent with the occurrence of Knirps-dCtBP interactions in vivo. These observations suggest that CtBP and dCtBP are engaged in an evolutionarily conserved mechanism of transcriptional repression, which is used in both Drosophila and mammals.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalScience
Volume280
Issue number5360
DOIs
StatePublished - Apr 3 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

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