TY - JOUR
T1 - Inter-subject alignment of human cortical anatomy using functional connectivity
AU - Conroy, Bryan R.
AU - Singer, Benjamin D.
AU - Guntupalli, J. Swaroop
AU - Ramadge, Peter J.
AU - Haxby, James V.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Inter-subject alignment of functional MRI (fMRI) data is necessary for group analyses. The standard approach to this problem matches anatomical features of the brain, such as major anatomical landmarks or cortical curvature. Precise alignment of functional cortical topographies, however, cannot be derived using only anatomical features.We propose a new inter-subject registration algorithm that aligns intra-subject patterns of functional connectivity across subjects. We derive functional connectivity patterns by correlating fMRI BOLD time-series, measured during movie viewing, between spatially remote cortical regions. We validate our technique extensively on real fMRI experimental data and compare our method to two state-of-the-art inter-subject registration algorithms. By cross-validating our method on independent datasets, we show that the derived alignment generalizes well to other experimental paradigms.
AB - Inter-subject alignment of functional MRI (fMRI) data is necessary for group analyses. The standard approach to this problem matches anatomical features of the brain, such as major anatomical landmarks or cortical curvature. Precise alignment of functional cortical topographies, however, cannot be derived using only anatomical features.We propose a new inter-subject registration algorithm that aligns intra-subject patterns of functional connectivity across subjects. We derive functional connectivity patterns by correlating fMRI BOLD time-series, measured during movie viewing, between spatially remote cortical regions. We validate our technique extensively on real fMRI experimental data and compare our method to two state-of-the-art inter-subject registration algorithms. By cross-validating our method on independent datasets, we show that the derived alignment generalizes well to other experimental paradigms.
KW - Functional connectivity
KW - Inter-subject registration
KW - Surface-based methods
UR - http://www.scopus.com/inward/record.url?scp=84879497052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879497052&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2013.05.009
DO - 10.1016/j.neuroimage.2013.05.009
M3 - Article
C2 - 23685161
AN - SCOPUS:84879497052
VL - 81
SP - 400
EP - 411
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -