Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO

Jessica N. Landis, Coleen T. Murphy

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.

Original languageEnglish (US)
Pages (from-to)1405-1412
Number of pages8
JournalDevelopmental Dynamics
Issue number5
StatePublished - May 2010

All Science Journal Classification (ASJC) codes

  • Developmental Biology


  • Aging
  • C. elegans
  • DAF-16
  • DAF-2
  • FOXO
  • Insulin
  • Longevity


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