Insulating behavior of lambda-DNA on the micron scale

Y. Zhang; R. H. Austin; J. Kraeft; E. C. Cox; N. P. Ong

Insulating behavior of lambda-DNA on the micron scale

Y. Zhang, R. H. Austin, J. Kraeft, E. C. Cox, N. P. Ong

Research output: Contribution to journal › Article › peer-review

Abstract

We have investigated the electrical conductivity of lambda-DNA using DNA covalently bonded to Au electrodes. Thiol-modified dTTP was incorporated into the "sticky" ends of bacteriophage lambda-DNA using DNA polymerase. Two-probe measurements on such molecules provide a hard lower bound for the resistivity rho>10(6)Omega cm at bias potentials up to 20 V, in conflict with recent claims of moderate to high conductivity. By direct imaging, we show that the molecules are present after the measurements. We stress the importance of eliminating salt residues in these measurements.

Original language	English (US)
Pages (from-to)	198102
Number of pages	1
Journal	Physical review letters
Volume	89
Issue number	19
State	Published - Nov 4 2002

All Science Journal Classification (ASJC) codes

General Physics and Astronomy

Cite this

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AU - Austin, R. H.

AU - Kraeft, J.

AU - Cox, E. C.

AU - Ong, N. P.

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N2 - We have investigated the electrical conductivity of lambda-DNA using DNA covalently bonded to Au electrodes. Thiol-modified dTTP was incorporated into the "sticky" ends of bacteriophage lambda-DNA using DNA polymerase. Two-probe measurements on such molecules provide a hard lower bound for the resistivity rho>10(6)Omega cm at bias potentials up to 20 V, in conflict with recent claims of moderate to high conductivity. By direct imaging, we show that the molecules are present after the measurements. We stress the importance of eliminating salt residues in these measurements.

AB - We have investigated the electrical conductivity of lambda-DNA using DNA covalently bonded to Au electrodes. Thiol-modified dTTP was incorporated into the "sticky" ends of bacteriophage lambda-DNA using DNA polymerase. Two-probe measurements on such molecules provide a hard lower bound for the resistivity rho>10(6)Omega cm at bias potentials up to 20 V, in conflict with recent claims of moderate to high conductivity. By direct imaging, we show that the molecules are present after the measurements. We stress the importance of eliminating salt residues in these measurements.

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JO - Physical review letters

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ER -

Insulating behavior of lambda-DNA on the micron scale

Abstract

All Science Journal Classification (ASJC) codes

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