Inhaled nitric oxide use and outcomes in critically ill children with a history of prematurity

Eunice Kennedy Shriver National Institute of Child Health, Human Development Collaborative Pediatric Critical Care Research Network

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Inhaled nitric oxide (INO) is used to treat hypoxic respiratory failure without clear evidence of benefit. Future trials to evaluate its use will be designed based on an understanding of the populations in which this therapy is provided and with outcomes based on patient characteristics, for example, a history of premature birth. METHODS: This was a multicenter prospective observational study that evaluated subjects in the pediatric ICU who were treated with INO for a respiratory indication, excluding those treated in the neonatal ICU or treated for birth-related disease. We used logistic regression to evaluate characteristics associated with mortality and duration of mechanical ventilation. Specifically, we compared subjects born early preterm (<32 weeks post-conceptual age), late preterm (32-37 weeks postconceptual age), and full term. RESULTS: A total of 163 children (median age [interquartile range], 1.8 [0.7-6.0] y) were included, 41 (25.2%) had a history of preterm birth (18 born early preterm and 23 born late preterm). INO was initiated for less-severe lung disease in the early preterm versus late preterm versus full-term subjects (median mean airway pressures, 16 vs 19 vs 19 cm H2O; P 5.03), although the oxygenation index and oxygenation saturation index did not differ. The early preterm subjects had more ventilator-free days (median, 18.0, 7.0, 4.5 d; P 5.02) and lower 28-d mortality (0, 26.1, 32.0%; P 5.007). Lower respiratory tract disease, but not a history of prematurity, was independently associated with lower mortality. CONCLUSIONS: INO was used differently in early preterm subjects. Clinical trials that evaluate INO use should have standardized oxygenation deficit thresholds for initiation of therapy and should consider stratifying by early preterm status.

Original languageEnglish (US)
Pages (from-to)1549-1559
Number of pages11
JournalRespiratory Care
Issue number10
StatePublished - Oct 1 2021

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine


  • Acute Respiratory Distress Syndrome
  • Critical care outcomes
  • Infant
  • Nitric oxide
  • Pediatric
  • Premature
  • Pulmonary hypertension
  • Right ventricular failure


Dive into the research topics of 'Inhaled nitric oxide use and outcomes in critically ill children with a history of prematurity'. Together they form a unique fingerprint.

Cite this