Ingestible Bioelectronics: A Packaged, Bio-Molecular, Fluorescence-Based Sensor Array with Ultra-Low-Power Wireless Interface

Chengjie Zhu, Lingyu Hong, Haw Yang, Kaushik Sengupta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ingestible electronics capable of laboratory quality bio-molecular analysis occupying pill-sized volume, operating at sub-mW with a robust wireless interface can transform medical diagnostics and personalized healthcare. Miniaturization of complex bio-molecular systems in such a volume is extremely challenging, notwithstanding a wireless interface that is capable of robust communication through inches of tissue. The paper presents a fully packaged biosensor system with Tx/Rx antennas coupled to a single CMOS chip that integrates a low-power wireless interface and a 15-pixel fluorescence biosensor array with on-chip nanoplasmonic optical filters. The IC, operating across multiple ISM/MICS bands, employs pulse-pause-encoded ASK/OOK modulation and achieves reception energy efficiency of 28 pJ/bit at 7 Mbps and -58 dBm of sensitivity with 196 μW of DC power. The entire bio-compatible package is miniaturized to a size of 1.2 × 2.5 cm. To the best of the authors' knowledge, this work demonstrates for the first time a CMOS ICs with pM sensitivity in protein/DNA assays with wireless transmission capability through inches of tissue at state of the art energy efficiency.

Original languageEnglish (US)
Title of host publication2019 IEEE MTT-S International Microwave Symposium, IMS 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages212-215
Number of pages4
ISBN (Electronic)9781728113098
DOIs
StatePublished - Jun 2019
Event2019 IEEE MTT-S International Microwave Symposium, IMS 2019 - Boston, United States
Duration: Jun 2 2019Jun 7 2019

Publication series

NameIEEE MTT-S International Microwave Symposium Digest
Volume2019-June
ISSN (Print)0149-645X

Conference

Conference2019 IEEE MTT-S International Microwave Symposium, IMS 2019
CountryUnited States
CityBoston
Period6/2/196/7/19

All Science Journal Classification (ASJC) codes

  • Radiation
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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    Zhu, C., Hong, L., Yang, H., & Sengupta, K. (2019). Ingestible Bioelectronics: A Packaged, Bio-Molecular, Fluorescence-Based Sensor Array with Ultra-Low-Power Wireless Interface. In 2019 IEEE MTT-S International Microwave Symposium, IMS 2019 (pp. 212-215). [8700834] (IEEE MTT-S International Microwave Symposium Digest; Vol. 2019-June). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/mwsym.2019.8700834