Influenza virus rna synthesis and the innate immune response

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Infection with influenza A and B viruses results in a mild to severe respiratory tract infection. It is widely accepted that many factors affect the severity of influenza disease, including viral replication, host adaptation, innate immune signalling, pre-existing immunity, and secondary infections. In this review, we will focus on the interplay between influenza virus RNA synthesis and the detection of influenza virus RNA by our innate immune system. Specifically, we will discuss the generation of various RNA species, host pathogen receptors, and host shut-off. In addition, we will also address outstanding questions that currently limit our knowledge of influenza virus replication and host adaption. Understanding the molecular mechanisms underlying these factors is essential for assessing the pandemic potential of future influenza virus outbreaks.

Original languageEnglish (US)
Article number780
Issue number5
StatePublished - May 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology


  • Defective interfering RNA
  • Influenza A virus
  • Interferon
  • MAVS
  • Mini viral RNA
  • RIG-I
  • RNA polymerase


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