Inference on tissue transplantation experiments

Yue Wang, Boyu Zhang, Jérémie Kropp, Nadya Morozova

Research output: Contribution to journalArticlepeer-review

Abstract

We review studies on tissue transplantation experiments for various species: one piece of the donor tissue is excised and transplanted into a slit in the host tissue, then observe the behavior of this grafted tissue. Although we have known the results of some transplantation experiments, there are many more possible experiments with unknown results. We develop a penalty function-based method that uses the known experimental results to infer the unknown experimental results. Similar experiments without similar results get penalized and correspond to smaller probability. This method can provide the most probable results of a group of experiments or the probability of a specific result for each experiment. This method is also generalized to other situations. Besides, we solve a problem: how to design experiments so that such a method can be applied most efficiently.

Original languageEnglish (US)
Article number110645
JournalJournal of Theoretical Biology
Volume520
DOIs
StatePublished - Jul 7 2021

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Keywords

  • Experimental design
  • Experimental result inference
  • Penalty function
  • Similarity between experiments

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