Infection trains the host for microbiota-enhanced resistance to pathogens

Apollo Stacy, Vinicius Andrade-Oliveira, John A. McCulloch, Benedikt Hild, Ji Hoon Oh, P. Juliana Perez-Chaparro, Choon K. Sim, Ai Ing Lim, Verena M. Link, Michel Enamorado, Giorgio Trinchieri, Julia A. Segre, Barbara Rehermann, Yasmine Belkaid

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Previous intestinal infection increases the gut microbiota's resistance to subsequent infection by inhibiting the ability of pathogens to respire.

Original languageEnglish (US)
Pages (from-to)615-627.e17
JournalCell
Volume184
Issue number3
DOIs
StatePublished - Feb 4 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology

Keywords

  • Citrobacter rodentium
  • Enterococcus faecalis
  • Klebsiella pneumoniae
  • aerobic respiration
  • bile acid
  • bismuth subsalicylate
  • colonization resistance
  • gut microbiome
  • hydrogen sulfide
  • taurine

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