Without doubt the basic reproductive ratio, R0, is the most widely used quantity in epidemic theory. Standard compartmental models show how R0 is related to the average age of infection, vaccination thresholds for eradication and equilibrium solutions. However, many of the basic formulae for R0 break down when we consider transmission of infection to be a stochastic process involving discrete individuals. This paper clarifies why and when these differences arise and predicts when individual-based considerations are likely to be important in modelling infection dynamics. (C) 2000 Academic Press.
All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Modeling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics