Increased anxiety of mice lacking the serotonin1A receptor

Christopher L. Parks, Patricia S. Robinson, Etienne Sibille, Thomas Shenk, Miklos Toth

Research output: Contribution to journalArticle

572 Scopus citations

Abstract

Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.

Original languageEnglish (US)
Pages (from-to)10734-10739
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number18
DOIs
StatePublished - Sep 1 1998

All Science Journal Classification (ASJC) codes

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