Incomplete host immunity favors the evolution of virulence in an emergent pathogen

Arietta E. Fleming-Davies, Paul D. Williams, André A. Dhondt, Andrew P. Dobson, Wesley M. Hochachka, Ariel E. Leon, David H. Ley, Erik E. Osnas, Dana M. Hawley

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Immune memory evolved to protect hosts from reinfection, but incomplete responses that allow future reinfection may inadvertently select for more-harmful pathogens. We present empirical and modeling evidence that incomplete immunity promotes the evolution of higher virulence in a natural host-pathogen system. We performed sequential infections of house finches with Mycoplasma gallisepticum strains of various levels of virulence. Virulent bacterial strains generated stronger host protection against reinfection than less virulent strains and thus excluded less virulent strains from infecting previously exposed hosts. In a two-strain model, the resulting fitness advantage selected for an almost twofold increase in pathogen virulence. Thus, the same immune systems that protect hosts from infection can concomitantly drive the evolution of more-harmful pathogens in nature.

Original languageEnglish (US)
Pages (from-to)1030-1033
Number of pages4
JournalScience
Volume359
Issue number6379
DOIs
StatePublished - Mar 2 2018

All Science Journal Classification (ASJC) codes

  • General

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