In vivo models of hepatitis B and C virus infection

Benjamin Y. Winer, Qiang Ding, Jenna M. Gaska, Alexander Ploss

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Globally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.

Original languageEnglish (US)
Pages (from-to)1987-1999
Number of pages13
JournalFEBS Letters
DOIs
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • hepatitis B virus
  • hepatitis C virus
  • hepatitis delta virus
  • mouse models
  • surrogate models

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