In vitro processing of E. coli tRNA precursors

Paul Schedl, John Roberts, Paul Primakoff

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Using E. coli tRNA precursors isolated from an RNAase P mutant strain, we have studied the steps required for the formation of tRNAs having a mature primary sequence in vitro. Our results suggest that at least three different enzymatic activities can participate in the processing of tRNA precursors.

Original languageEnglish (US)
Pages (from-to)581-594
Number of pages14
Issue number4
StatePublished - Aug 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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