Abstract
Mid-infrared transmission spectroscopy using broadband midinfrared or Quantum Cascade laser sources is used to predict glucose concentrations of aqueous and serum solutions containing physiologically relevant amounts of glucose (50-400 mg/dL). We employ partial least squares regression to generate a calibration model using a subset of the spectra taken and to predict concentrations from new spectra. Clinically accurate measurements with respect to a Clarke error grid were made for concentrations as low as 30 mg/dL, regardless of background solvent. These results are an important and encouraging step in the work towards developing a noninvasive in vivo glucose sensor in the mid-infrared.
Original language | English (US) |
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Pages (from-to) | 1083-1090 |
Number of pages | 8 |
Journal | Biomedical Optics Express |
Volume | 4 |
Issue number | 7 |
DOIs | |
State | Published - 2013 |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Atomic and Molecular Physics, and Optics