In vitro measurements of physiological glucose concentrations in biological fluids using mid-infrared light

Sabbir Liakat, Kevin A. Bors, Tzu Yung Huang, Anna P.M. Michel, Eric Zanghi, Claire F. Gmachl

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Mid-infrared transmission spectroscopy using broadband midinfrared or Quantum Cascade laser sources is used to predict glucose concentrations of aqueous and serum solutions containing physiologically relevant amounts of glucose (50-400 mg/dL). We employ partial least squares regression to generate a calibration model using a subset of the spectra taken and to predict concentrations from new spectra. Clinically accurate measurements with respect to a Clarke error grid were made for concentrations as low as 30 mg/dL, regardless of background solvent. These results are an important and encouraging step in the work towards developing a noninvasive in vivo glucose sensor in the mid-infrared.

Original languageEnglish (US)
Pages (from-to)1083-1090
Number of pages8
JournalBiomedical Optics Express
Volume4
Issue number7
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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